Individual and Dyadic Health-Related Quality of Life of People Living with Dementia and their Caregivers

AbstractMany interventions target dyads of people living with Alzheimer ’s disease and related dementias (ADRD) and their caregivers. Without a dyadic measure of health-related quality of life (HRQOL), cost-utility analyses of these interventions require using the HRQOL of people with ADRD and caregivers, separately. We developed a dyadic measure of HRQOL that incorpo rates the interdependence between HRQOL of people living with ADRD and their caregivers and measures the dyad’s collective benefits. First, we estimated dyadic HRQOL time trade-off-weights (TTO-weights), a dyadic preference-based measure of HRQOL. Second, we estimated the association between ADRD clinical features and TTO-weights. We used the Aging, Demographics, and Memory Study to identify people living with ADRD (n = 308) and their caregivers (n = 160 dyads) and predict their TTO-weights. We estimated dyadic TTO-weights using an Archimedean bivariate utility copula with a quadrati c generating function. Finally, we used adjusted linear regression to examine the association between predicted TTO-weights and ADRD clinical features. Average (standard deviation) TTO-weights of people living with ADRD, and caregivers were 0.67 (0.14) and 0.83 (0.09), respectively. Average dyadic T TO-weight was 0.75(0.05). When the dyadic TTO-weight was ≤ 0.60, an increase in the TTO-weight of the dyad-member with the lowest HRQOL resulted in a larger gain in the dyadic TTO-weight than a similar increase in the T...
Source: Applied Research in Quality of Life - Category: International Medicine & Public Health Source Type: research