Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy

CONCLUSIONS: In conclusion, these findings highlight the dark side of persistent Nrf2 activation and potential crosstalk among Pb-induced persistent Nrf2 activation, apoptosis and autophagy blockage in Pb-triggered nephrotoxicity.PMID:37003700 | DOI:10.1016/j.jare.2022.04.016

Source: Adv Data - April 1, 2023 Category: Epidemiology Authors: Cai-Yu Lian Bing-Xin Chu Wei-Hao Xia Zhen-Yong Wang Rui-Feng Fan Lin Wang Source Type: research