Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics

Conclusions: Asc restoration in cultured cells dramatically alters their stress responses to Cr(VI) by preventing activation of the oxidant-sensitive ATM network. We suggest that toxicogenomic and other cell response-based approaches likely underestimate Cr(VI) genotoxicity when standard ATM-activating carcinogens are used as references.

This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Luczak MW, Green SE, Zhitkovich A. Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409434.
Received: 5 November 2014
Accepted: 13 May 2015
Advance Publication: 15 May 2015
EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [e-mail]. Our staff will work with you to assess and meet...

Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research