Severe sleep apnea as a predictor of failure to respond to cardiac resynchronization therapy

Sleep-disordered breathing (SDB) of at least moderate severity with an apnea-hypopnea index (AHI) of ≥15 events per hour (events/h) is found in approximately 50% of patients with congestive heart failure (CHF) and more often in case of men.1,2,3 The risk of developing SDB in this population increases by 10% for every 5% reduction in left ventricular ejection fraction (LVEF).1 Their occurrence is favored by low cardiac output (CO) with a prolonged circulatory delay and unstable ventilatory control during sleep, as well as increased left ventricular (LV) filling pressure and pulmonary congestion.

Source: Heart and Lung - February 16, 2023 Category: Intensive Care Authors: Danuta Łoboda, Jacek Wilczek, Karolina Simionescu, Jolanta Biernat, Tomasz Jadczyk, Wojciech Wojakowski, Krzysztof S. Gołba Source Type: research