Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population

Suicidal behavior is a worldwide health problem. Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the biosynthesis of serotonergic neurotransmission. TPH-1 and TPH-2 genes encode for TPH isoforms and have been implicated as candidate genes for suicidal behavior. The aim of this study was to evaluate the association between the genetic variants of the TPH-1 (rs21102 and 1607395) and TPH-2 (rs4290270, rs7305115 and rs1007023) genes and suicidal behavior in a Mexican population.

http://www.comppsychjournal.com/article/S0010-440X(15)00066-8/abstract?rss=yes

Source: Comprehensive Psychiatry - May 13, 2015 Category: Psychiatry Authors: María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Thelma Beatriz González-Castro, Isela Juárez-Rojop, Sherezada Pool-García, Alma Genis, Jorge L. Ble-Castillo, Ana Fresán Source Type: research