Angiopoietin-1 inhibits toll-like receptor 4 signalling in cultured endothelial cells: role of miR-146b-5p

Conclusion
Ang-1 disrupts TLR4 signalling, resulting in inhibition of LPS-induced inflammatory responses in endothelial cells. This inhibition occurs through selective targeting of IRAK1 and TRAF6 proteins by miR-146b-5p.

Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Echavarria, R., Mayaki, D., Neel, J.-C., Harel, S., Sanchez, V., Hussain, S. N. A. Tags: Vascular biology Source Type: research