Detection of an atypical BCR::ABL1 fusion in a patient with secondary B-cell acute lymphoblastic leukemia/lymphoma following multiple myeloma treatment

We present a case of a secondary Ph+ B-ALL following multiple myeloma that highlights a BCR::ABL1 fusion by a gene fusion assay to reveal a cryptic Ph chromosome, which may otherwise be missed by conventional cytogenetics and typical interphase fluorescence in situ hybridization.

Source: Cancer Genetics and Cytogenetics - March 18, 2023 Category: Genetics & Stem Cells Authors: Karin Miller, Jonathan Webster, Philip Imus, Candice Ament, Melanie Hardy, Ying S. Zou Source Type: research