CD3+CD56+ and CD3 −CD56+ lymphocytes in the cerebrospinal fluid of persons with HIV-1 subtypes B and C

The transactivator of transcription (Tat) is a HIV regulatory protein which promotes viral replication and chemotaxis. HIV-1 shows extensive genetic diversity, HIV-1 subtype C being the most dominant subtype in the world. Our hypothesis is the frequency of CSF CD3+CD56+ and CD3 −CD56dim is reduced in HIV-1C compared to HIV-1B due to the Tat C30S31 substitution in HIV-1C. 34 CSF and paired blood samples (PWH, n = 20; PWoH, n = 14) were studied. In PWH, the percentage of CD3+CD56+ was higher in CSF than in blood (p 

Source: Journal of Neuroimmunology - March 17, 2023 Category: Allergy & Immunology Authors: Sergio M. de Almeida, Miriam Perlingeiro Beltrame, Bin Tang, Indianara Rotta, Julie Lilian P. Justus, Yara Schluga, Maria Tadeu da Rocha, Edna Martins, Antony Liao, Ian Abramson, Florin Vaida, Rachel Schrier, Ronald J. Ellis Source Type: research