The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders

This study aimed to evaluate the role of TREM1 in sevoflurane-induced PND. We applied AAV knockdown TREM1 in hippocampal microglia in aging mice. The mice were then subjected to neurobehavioral and biochemical testing after the intervention of sevoflurane.

Source: Journal of Neuroimmunology - March 15, 2023 Category: Allergy & Immunology Authors: Chunchun Tang, Xue Zheng, Yuanping Zhong, Dongqin Chen, Yuhang Zhu, Sihui Wang, Liulin Xiong, Zhaoqiong Zhu Source Type: research