Bilateral ovarian fibromas in premenarchal girl with Gorlin-Goltz syndrome

Ovarian fibromas in children are atypical, in approximately 10% of the cases they are reported as bilateral. In premenarchal females can be a manifestation of Gorlin-Goltz syndrome, rare autosomal dominant disorder (1/60.000) with multisystemic developmental abnormalities, caused by mutations of the PTCH1 gene.A notable case of an eight-year-old female with Gorlin-Goltz syndrome and bilateral ovarian fibromas is presented. At the age of 11 months, she was diagnosed with desmoplastic medulloblastoma.

Source: Journal of Pediatric and Adolescent Gynecology - March 11, 2023 Category: OBGYN Authors: Marina Jakimovska Stefanovska, Jure Gruntar, Lidija Kitanoski Source Type: research