In vitro efficacy of plumbagin and thymol against Theileria annulata

AbstractPhytochemical compounds, plumbagin and thymol were evaluated for their efficacy againstTheileria annulata using MTT cell viability assay. Plumbagin and thymol were found to be effective in preventing the proliferation ofTheileria annulata infected bovine lymphocytes. The IC50 values of plumbagin and thymol were 0.019  µM and 0.009 µM, respectively. Plumbagin and thymol were found to be non-cytotoxic to the bovine peripheral blood mononuclear cells. However, both the compounds were found to have inhibitory effect on vero cell proliferation. Plumbagin had primarily anti-theilerial activity but thymol had prima rily anti-mitotic activity. The in vitro efficacy and cell toxicity studies indicate the potential application of plumbagin, purified fromPlumbago indica as a lead therapeutic molecule againstT. annulata infection in cattle.Graphical Abstract
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research