Molecules, Vol. 28, Pages 2492: Solid & ndash;Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction

Molecules, Vol. 28, Pages 2492: Solid–Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction Molecules doi: 10.3390/molecules28062492 Authors: Alžběta Zemánková Fatima Hassouna Martin Klajmon Michal Fulem In this work, the solid–liquid equilibrium (SLE) of four binary systems combining two active pharmaceutical ingredients (APIs) capable of forming co-amorphous systems (CAMs) was investigated. The binary systems studied were naproxen-indomethacin, naproxen-ibuprofen, naproxen-probucol, and indomethacin-paracetamol. The SLE was experimentally determined by differential scanning calorimetry. The thermograms obtained revealed that all binary mixtures investigated form eutectic systems. Melting of the initial binary crystalline mixtures and subsequent quenching lead to the formation of CAM for all binary systems and most of the compositions studied. The experimentally obtained liquidus and eutectic temperatures were compared to theoretical predictions using the perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state and conductor-like screening model for real solvents (COSMO-RS), as implemented in the Amsterdam Modeling Suite (COSMO-RS-AMS). On the basis of the obtained results, the ability of these models to predict the phase diagrams for the investigated API–API binary systems was evaluated. Furthermore, the glass transition temperature (Tg) of naproxen (NAP), a compound with a high ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research