Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain

ConclusionsThe temporal shift inKp,uu among the different molecular forms provides evidence regarding the operation of carrier-mediated transport and/or within-brain metabolism of bupropion, and, thereby, fresh insight regarding the causes of intersubject variability in the safety and efficacy of bupropion therapy.

http://link.springer.com/10.1007/s13318-023-00817-9

Source: European Journal of Drug Metabolism and Pharmacokinetics - February 23, 2023 Category: Drugs & Pharmacology Source Type: research