Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol

High-fat diet can exacerbate tissue inflammatory disorders such as psoriasis, but molecular mechanisms linking dietary components and tissue lymphocyte responses are scarce. Here, Frascoli et  al. report that dermal innate-like lymphocytes require cholesterol metabolites sensing for thymic development and skin homeostasis. Dietary cholesterol enhances their activation and exacerbates tissue inflammation.

Source: Immunity - February 24, 2023 Category: Allergy & Immunology Authors: Michela Frascoli, Enxhi Ferraj, Bing Miu, Justin Malin, Nicholas A. Spidale, Jennifer Cowan, Susanna C. Shissler, Robert Brink, Ying Xu, Jason G. Cyster, Avinash Bhandoola, Joonsoo Kang, Andrea Reboldi Tags: Article Source Type: research