Axonal and presynaptic FMRP: Localization, signal, and functional implications

Hear Res. 2023 Feb 11;430:108720. doi: 10.1016/j.heares.2023.108720. Online ahead of print.ABSTRACTFragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.PMID:36809742 | DOI:10.1016/j.heares.2023.108720
Source: Hearing Research - Category: Audiology Authors: Source Type: research