Decision-making and regret in patients with germline CDH1 variants undergoing prophylactic total gastrectomy

Conclusion
The decision to undergo PTG is influenced by family cancer history and surveillance endoscopy results. Regret is associated with surgical complications and pathological absence of cancer. Individual cancer-risk assessment is necessary to improve pre-operative counselling and inform the decision-making process.

Trial registration number
NCT03030404.

Source: Journal of Medical Genetics - February 23, 2023 Category: Genetics & Stem Cells Authors: Gamble, L. A., Grant, R. R. C., Samaranayake, S. G., Fasaye, G.-A., Koh, C., Korman, L., Asif, B., Heller, T., Hernandez, J. M., Blakely, A. M., Davis, J. L. Tags: Cancer genetics Source Type: research