Evaluation of haematological and biochemical  changes following xylazine, tramadol and lignocaine premedicated propofol anaesthesia in West African dwarf goat

This study was conducted to evaluate the haematological and biochemical changes during propofol anaesthesia in West African dwarf goat. Four groups A, B, C and D of five (5) goats in each group received normal saline (2  ml, IV), xylazine (0.05 mg/kg body weight, IV), tramadol (2 mg/kg, IV) and lignocaine (2.5 mg/kg, SC) respectively as premedicants. Each goat in all the groups was anaesthesized with propofol at 9 mg/kg body weight (b/w). The biochemical and haematological parameters were determined pre-induct ion and post-induction of the anaesthesia. Blood was collected through the jugular vein using a 5-ml syringe and 21-gauge needle. There was a significant increase in packed cell volume (PCV) in group C at 60 min post-induction. A decrease in haemoglobin concentration and white blood cells (WBC) was observed in group B. Glucose levels increased significantly in groups A and B within 20 and 40 min post-induction. There was a transient increase in AST level in group C. The blood urea nitrogen (BUN) increased post-inductions in all the groups, especially in group C. Most of these changes were w ithin the normal range in goats. It is concluded that the propofol combinations are safe to use in goats.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research