Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir

Respiratory infection can trigger exacerbation of emphysema, but we lack understanding of the processes involved. Wang et  al. show that alteration of a COPD variant gene in the stroma can potentiate tissue-resident lymphocyte expansion that suppresses stem cell renewal, leading to loss of barrier surface and emphysema in the lung.

Source: Immunity - February 22, 2023 Category: Allergy & Immunology Authors: Chaoqun Wang, Ben Hyams, Nancy C. Allen, Kelly Cautivo, Kiara Monahan, Minqi Zhou, Madelene W. Dahlgren, Carlos O. Lizama, Michael Matthay, Paul Wolters, Ari B. Molofsky, Tien Peng Tags: Article Source Type: research