A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer ’s Disease (AD). Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mu...

Source: Molecular Neurodegeneration - February 17, 2023 Category: Neurology Authors: Kristine M. Tran, Shimako Kawauchi, Enik ö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S. Sakr, Angela Gomez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Tags: Research article Source Type: research