Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

Cell Death Dis. 2023 Feb 11;14(2):105. doi: 10.1038/s41419-023-05639-w.ABSTRACTCopper is a vital mineral, and an optimal amount of copper is required to support normal physiologic processes in various systems, including the cardiovascular system. Over the past few decades, copper-induced cell death, named cuproptosis, has become increasingly recognized as an important process mediating the pathogenesis and progression of cardiovascular disease (CVD), including atherosclerosis, stroke, ischemia-reperfusion injury, and heart failure. Therefore, an in-depth understanding of the regulatory mechanisms of cuproptosis in CVD may be useful for improving CVD management. Here, we review the relationship between copper homeostasis and cuproptosis-related pathways in CVD, as well as therapeutic strategies addressing copper-induced cell death in CVD.PMID:36774340 | PMC:PMC9922317 | DOI:10.1038/s41419-023-05639-w

Source: Atherosclerosis - February 11, 2023 Category: Cardiology Authors: Xinyue Chen Qi Cai Ruikai Liang Deju Zhang Xiao Liu Meiying Zhang Yan Xiong Minxuan Xu Qi Liu Pengyang Li Peng Yu Ao Shi Source Type: research