SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway

In conclusions, the S-protein of SARS-Cov-2 induces cellular senescence of ARPE-19 cells in vitro and the expression of senescence-associated cytokines in zebrafish retina in vivo likely by activating ER stress, ROS, and NF-κb. These results may uncover a potential association between SARS-cov-2 infection and development of AMD.PMID:36738354 | PMC:PMC9898700 | DOI:10.1007/s10522-023-10019-0

Source: Biogerontology - February 4, 2023 Category: Geriatrics Authors: Yuhang Zhang Xuyan Peng Mengjiao Xue Jingjing Liu Guohui Shang Mingjun Jiang Dandan Chen Baixue Liu Yuxuan Wang Xiaolin Jia Jianqing Xu Fengyan Zhang Yanzhong Hu Source Type: research