Paraventricular Nucleus of the Hypothalamus Oxytocin and Incubation of Heroin Seeking

Discussion: These findings reinforce oxytocin’s therapeutic pot ential for OUD, the basis for which may be driven in part by increased PVN-CeA circuit activity. Our results also suggest that oxytocin has distinct signaling and/or other mechanisms of action to produce these effects, as inhibition, but not activation, of oxytocinergic PVN neurons did not recapitul ate the suppression in heroin seeking.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research