Therapeutic potential of thiophene compounds: a mini-review

Mini Rev Med Chem. 2023 Feb 6. doi: 10.2174/1389557523666230206104257. Online ahead of print.ABSTRACTA rising number of researchers are interested in thiophene-based analogs as they have wide possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety. It also occupies a central position in synthetic organic chemistry and is of the highest theoretical and practical importance. It became an important moiety for researchers to discover combinatorial libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists to improve sophisticated molecules with a broad range of pharmacological activities. Thiophene and its synthetic derivatives are a prominent heterocyclic compound class with intriguing uses in medical chemistry. It has been manifesting to be an effective drug in current respective diseases scenario. It has been discovered that thiophene has an extensive spectrum of pharmacological potential with numerous applications in academic interest, in the pharmaceutical industry, material science, and medicinal chemistry. Antimitotic, Antimicrobial, Anti-inflammatory, Anticonvulsant, Antipsychotic, Antiarrhythmic, Anti-anxiety, Antifungal, Antioxidant, Estrogen receptor regulating, and Anti-cancer are one of the pharmacological and physiological activities of thiophene moiety. However, there are some marketed formulations available such as Thiophenfurin, Teniposide, Cefoxitin, Ticaconazole, Sert...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research