Common mouse models of tauopathy reflect early but not late human disease

Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer ’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were...

Source: Molecular Neurodegeneration - February 2, 2023 Category: Neurology Authors: Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen and Judith A. Tags: Research article Source Type: research