Intestinal steroidogenesis controls PPAR{gamma} expression in the colon and is impaired during ulcerative colitis

Conclusions
These results demonstrate cortisol control of PPAR expression in CEC, highlighting cortisol production deficiency in colonocytes as a key molecular event in the pathophysiology of UC.

Source: Gut - May 8, 2015 Category: Gastroenterology Authors: Bouguen, G., Langlois, A., Djouina, M., Branche, J., Koriche, D., Dewaeles, E., Mongy, A., Auwerx, J., Colombel, J.-F., Desreumaux, P., Dubuquoy, L., Bertin, B. Tags: Ulcerative colitis Inflammatory bowel disease Source Type: research