Magnetic Targeting Nanocarriers Combined with Focusing Ultrasound for Enhanced Intracerebral Hemorrhage Therapy

A magnetic targeting nanocarrier loaded with a peroxisome proliferator-activated receptor gamma agonist (15d-PGJ2-MNPs) is magnetically targeted to the area of the hematoma with the subsequent application of focusing ultrasound for alleviating brain injury, accelerating hematoma clearance, attenuating neuroinflammation, and reducing the brain edema in the intracerebral hemorrhage mouse model. AbstractIntracerebral hemorrhage (ICH) remains a significant cause of morbidity and mortality around the world, and surgery is still the most direct and effective way to remove ICH. However, the potential risks brought by surgery, such as normal brain tissue damage, post-operative infection, and difficulty in removing deep hematoma, are still the main problems in the surgical treatment of ICH. Activation of the peroxisome proliferator-activated receptor gamma (PPAR γ) is reported to show a good therapeutic effect in hematoma clearance. Herein, a magnetic targeting nanocarrier loaded with a PPARγ agonist (15d-PGJ2-MNPs) is synthesized, which could be magnetically targeted and enriched in the area of the hematoma after intravenous injection. Subsequent applica tion of focusing ultrasound (FUS) could enhance drug diffusion, which activates the PPARγ receptors on macrophages around the hematoma for better hematoma clearance. The 15d-PGJ2-MNP treatment alleviates brain injury, accelerates hematoma clearance, attenuates neuroinflammation, reduces brain edema and significantly improves the d...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research