In Chronic Spontaneous Urticaria, Complete Response to Antihistamine Treatment Is Linked to Low Disease Activity

In this study, we aimed to identify predictors of complete response to standard-dosed and higher than standard-dosed antihistamine treatments in patients with CSU.Methods: Medical records of 475 CSU patients, 120 of them #x3c;18 years old, from 3 different centers were analyzed. We used 15 machine learning (ML) models as well as traditional statistical methods to predict complete response to standard-dosed and higher than standard-dosed antihistamine treatment based on 17 clinical parameters.Results: CSU disease activity, which was assessed by urticaria activity score (UAS), was the only clinical parameter that predicted complete response to standard-dosed and higher than standard-dosed antihistamine treatment, with ML models and traditional statistics, for all age groups. Based on ROC analyses, optimal cut-off values of disease activity to predict complete response were UAS #x3c;3 and UAS #x3c;4 for standard-dosed (area under the ROC curve [AUC] = 0.69;p = 0.001) and higher than standard-dosed (AUC = 0.79;p = 0.001) antihistamine treatments, respectively. Also, ML models identified lower total IgE (#x3c;150 IU/mL) as a predictor of complete response to a standard-dosed antihistamine and lower CRP (#x3c;3.4 mg/mL) as a predictor of complete response to higher than standard-dose antihistamine treatment.Discussion: In this study, we showed that patients with UAS #x3c;3 are highly likely to have complete response to standard-dosed AH and those with a UAS #x3c;4 are highly likely...
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research