The effect of hereditary thrombotic factors and comorbidities on the severity of COVID-19 disease

CONCLUSIONS: The presence of solid tumors in patients with COVID-19 was related to the severity of the disease course. No evidence of a correlation between the severity of the disease and all five thrombotic mutations was found, whereas the FII G20210A and Beta-fibrinogen G-455A mutations were significantly high compared to previously reported Turkish population data and global carrier rates. This finding will need to be verified by further studies with larger samples since it may reflect a likelihood of having the COVID-19 disease. The high carrier frequency of FVL mutation was more likely present in the D-dimer high group generating an increase in the D-dimer levels 2.55-times compared to the wildtype.PMID:36647888 | DOI:10.26355/eurrev_202301_30893

Source: European Review for Medical and Pharmacological Sciences - January 17, 2023 Category: Drugs & Pharmacology Authors: M Kose N Senkal H Konyaoglu A Emet Y Oyaci S Pehlivan G Y Sayin Source Type: research