Late-onset efavirenz toxicity: A descriptive study from Pretoria, South Africa

Conclusion: Late-onset efavirenz toxicity typically presented with ataxia and encephalopathy, but psychosis can be the presenting feature. The outcome after withdrawal was good, but the mortality of 10.0% is concerning. Recent changes in guidelines favour dolutegravir, but many patients remain on efavirenz, a nd awareness of the condition is vital.What this study adds: This large, single-centre study contributes to the limited data of HIV-positive patients with late-onset efavirenz toxicity and emphasises its ongoing relevance in clinical practice.

Source: Southern African Journal of HIV Medicine - January 12, 2023 Category: African Health Authors: Lyneshree Munsami Source Type: research