Caveolin-1-deficient fibroblasts promote migration, invasion, and stemness via activating the TGF- β/Smad signaling pathway in breast cancer cells

This study refreshingly points out that CAV-1 deficiency in fibroblasts enhances TGF-β1 secretion and then activates the TGF-β1/Smad signaling pathway of BCCs, thus promoting the metastasis and stemness of BCCs. Collectively, our findings indicate an unexpected role of CAV-1 deficiency in fibroblasts and the tumor microenvironment as a permissive factor, which is regulated by the TGF-β1 signaling pathway in BCCs.PMID:36604141 | DOI:10.3724/abbs.2022150
Source: Acta Biochimica et Biophysica Sinica - Category: Biochemistry Authors: Source Type: research