Distinct Lymphocyte Immunophenotyping and Quantitative Anti-Interferon Gamma Autoantibodies in Taiwanese HIV-Negative Patients with Non-Tuberculous Mycobacterial Infections

ConclusionIn patients with suspected adult-onset immunodeficiency syndrome, two thirds (20/31) were recognized as having significantly inhibitory AutoAbs-IFN- γ with higher antibody-enhancing transitional, CD19 + CD21-low and plasmablast B cells; as well as higher effector memory, senescent CD8 + CD57 + and Th17 cells, but lower naïve T and Treg cells in contrast to those with negligible AutoAbs-IFN-γ. Such immunophenotyping disturbances mi ght correlate with the presence of AutoAbs-IFN-γ. However, the mutual mechanisms need to be further clarified.

http://link.springer.com/10.1007/s10875-022-01423-1

Source: Journal of Clinical Immunology - January 10, 2023 Category: Allergy & Immunology Source Type: research