Influence of sleeve gastrectomy on skeletal muscular fat infiltration measured by MRI in patients with metabolic syndrome - preliminary results

Introduction: Several researchers focused on the role of skeletal muscle in metabolic problems in recent years. We aimed to evaluate influence of sleeve gastrectomy on skeletal muscular fat infiltration determined by magnetic resonance imaging in patients with metabolic syndrome (MetS). Methods: 65 MetS patients (male/female 20/45; mean age, 35.3 years ± 6.7 [standard deviation]; age range, 22 – 59 years) enrolled in our study. Prior to and one year after sleeve gastrectomy, patients underwent routine measurement of skeletal muscular fat concentration (denoted by proton density fat fraction, PDFF) and chemical indexes. The associations of skele tal muscular fat concentration with other variables were determined using multiple backward linear regression analysis. Results: Difference between skeletal muscular PDFF at baseline (4.25 ± 2.05 %) and PDFF one-year after sleeve gastrectomy (2.91 ± 1.54 %) was significant. Multivariable predictor s of baseline skeletal muscular PDFF by descending order of standardized coefficient were fasting serum insulin (0.477; P = 0.001), fasting serum glucose (0.473; P
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research