Advances in the clinical management of uveal melanoma

Nature Reviews Clinical Oncology, Published online: 04 January 2023; doi:10.1038/s41571-022-00714-1Although almost all patients with uveal melanoma have localized disease at diagnosis, and despite effective treatment of the primary tumour, metastatic recurrence is common and holds a dismal prognosis. Unlike its cutaneous counterpart, therapeutic advances for uveal melanoma have not been forthcoming, although the recent approval of the first systemic therapy for this disease has ushered in a new era of hope. This Review summarizes the biology of uveal melanoma and the management of primary disease, including molecular risk classification, adjuvant therapy and follow-up strategies. The discussion is then focused on the established and emerging regional and systemic treatments for metastatic uveal melanoma.

Source: Nature Reviews Clinical Oncology - January 4, 2023 Category: Cancer & Oncology Authors: Richard D. Carvajal Joseph J. Sacco Martine J. Jager David J. Eschelman Roger Olofsson Bagge J. William Harbour Nicholas D. Chieng Sapna P. Patel Anthony M. Joshua Sophie Piperno-Neumann Source Type: research