TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells

Experimental & Molecular Medicine, Published online: 04 January 2023; doi:10.1038/s12276-022-00907-9New details of the molecular mechanisms behind problematic genetic aberrations that can affect cultured human embryonic stem cells could help efforts to maintain stable cell lines that hold great promise for treating a wide variety of diseases. Researchers in South Korea led by Hyuk-Jin Cha at Seoul National University investigated abnormalities in stem cell control systems leading to a condition known as survival advantage, which can allow abnormal cells to proliferate. They identified a gene (TPX2) whose expression activates another gene already known to be involved in triggering the survival advantage process. Their research further revealed that the protein encoded by TPX2 achieves this effect indirectly, by interacting with another protein known to be able to control the activity of specific genes. Revealing this molecular signaling chain could assist culture of stable stem cells.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research