TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury

The regulatory mechanisms involved in mitochondrial quality control (MQC) dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized. Transmembrane BAX inhibitor motif containing 6 (TMBIM6) is an endoplasmic reticulum protein with Ca2+ leak activity that modulates cellular responses to various cellular stressors.

Source: Metabolism - Clinical and Experimental - January 2, 2023 Category: Biomedical Science Authors: Hao Zhou, Zhe Dai, Jialei Li, Jin Wang, Hang Zhu, Xing Chang, Yijin Wang Source Type: research