Hantaan virus-induced elevation of plasma osteoprotegerin and its clinical implications in hemorrhagic fever with renal syndrome

Hemorrhagic fever with renal syndrome (HFRS) has gained widespread attention as a major public health concern (Brocato and Hooper,  2019). China is a severe endemic area where patients with HFRS, especially those infected with the Hantaan virus (HTNV) and Seoul virus, account for 90% of the total global cases (Jiang et al., 2017). Although hantavirus infections do not disrupt the vascular endothelium, the underlying pathogene sis of HFRS is undoubtedly related to increased vascular permeability and pronounced thrombocytopenia (Noack et al.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research