‘On-demand’ gene therapy for epilepsy

Nature Reviews Neurology, Published online: 12 December 2022; doi:10.1038/s41582-022-00761-3Gene therapies show promise for treating epilepsy, but most strategies target cells across an entire brain region rather than selecting pathologically hyperexcited neurons. Researchers have now developed a conditional gene therapy strategy that downregulates firing activity only in neurons that are pathologically overactive and switches off when brain circuit activity has returned to baseline.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research