Feasibility and Reaction Thresholds of Double-Blind, Placebo-Controlled Peanut and Nut Food Challenges Using Gingerbread Matrix

Conclusion: Seven percent of the children react on a starting dose of 1 mg of food protein. Therefore, when using the PRACTALL guidelines, early responders can be expected. Ingestion of a cumulative dose of 3,500 mg to reach a false-negative rate of maximum 5% is not feasible in most children using the gingerbread matrix. However, the cumulative dose may be reduced without increasing false-negative results, making challenges with the gingerbread matrix feasible for all age groups.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research