Helper T Cell 17 and Regulatory T Cell Levels in Peripheral Blood of Newly Diagnosed Patients with Autoimmune Thyroid Disease: A Meta-Analysis
This article aims to explore associated immune indicators of autoimmune thyroid
disease (AITD) through a meta-analysis of published case-control studies on
newly diagnosed AITD patients, intending to provide some suggestions for
research on the mechanisms of AITD. Six electronic databases were searched for
case-control studies on newly diagnosed AITD patients from inception to August
15, 2022. A random-effects model was used to calculate the standardized mean
difference (SMD), odds ratio (OR), and 95% confidence interval
(95% CI). A total of 26 articles were included in this meta-analysis.
Patients with newly diagnosed AITD had higher levels of helper T cell 17 (Th17)
(Hashimoto’s disease (HT): SMD=2.35, 95% CI: 1.98, 2.72;
Graves’ disease (GD): SMD=1.61, 95% CI: 1.23, 1.98),
lower levels of regulatory T cell (Treg) (HT: SMD=–2.04,
95% CI: –2.67, –1.42; GD: SMD=–1.35,
95% CI: –2.11, –0.58), and lower levels of forkhead box
P3 (FoxP3) mRNA (HT: SMD=–2.58, 95% CI: –3.12,
–2.05; GD: SMD=–2.13, 95% CI: –2.56,
–1.70), compared to the healthy population. In addition, the single
nucleotide polymorphism rs3761548 and rs3761549 in the promoter region of FoxP3
showed a higher frequency in the comparison of genotype “CT”
only in HT patients than in the healthy populati...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Chen, Aizhi Huang, Liang Zhang, Liqin Tags: Original Article: Endocrine Care Source Type: research