A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins

AbstractA new 1,2-diketone physalin, physalin XII (1), and 13 known compounds were isolated from the methanol extract ofPhysalis minima whole plant collected in Thailand. Among them, five physalins (2–6) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activity, and physalin F (3) was the most active with an IC50 value of 0.39  µM against human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL). An investigation of the TRAIL-resistance overcoming activity of physalins using western blot analysis showed that3 promoted TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research