Treatment of congenital hypothyroidism – impact of secular changes in levothyroxine initial dose on early growth

Conclusion: Current treatment practice with higher LT4 dose normalizes TSH rapidly without significant increase in side effects. However, irrespective of initial LT4 dose, children were shorter than expected at 2 years of age. Effects of different initial LT4 dose on cognitive development urges further investigation.
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research