A Human Vascularized Micro-Tumor Model of Patient-Derived Colorectal Cancer Recapitulates Clinical Disease

Accurately modeling tumor biology and testing novel therapies on patient-derived cells is critically important to developing therapeutic regimens personalized to a patient's specific disease. The vascularized micro-tumor (VMT), or "tumor-on-a-chip", is a physiologic preclinical cancer model that incorporates key features of the native human tumor microenvironment within a transparent microfluidic platform, allowing rapid drug screening in vitro. Herein we optimize methods for generating patient-derived VMT (pVMT) using fresh colorectal cancer (CRC) biopsies and surgical resections to test drug sensitivities at the individual patient level.

Source: Translational Research - December 5, 2022 Category: Research Authors: Stephanie J. Hachey, Agua Sobrino, John G. Lee, Mehraneh D. Jafari, Samuel J. Klempner, Eric J. Puttock, Robert A. Edwards, John S. Lowengrub, Marian L. Waterman, Jason A. Zell, Christopher C.W. Hughes Source Type: research