How does Arg16Gly polymorphism affect pulmonary function and treatment response in COPD patients?

Conclusions: Arg16Gly polymorphism of ADRB2 gene is affecting PFT in COPD patients. Arg16Arg is linked tolower FVC at all visitsy. Treatment response to LAMA/LABA combination was comparable in all groups, but mathematic model revealed different pattern in Arg16Arg genotype, which indicate tachyphylaxis of ADRB2 receptor.

Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Slepchenko, N., Mostovoy, Y., Dmytriiev, K., Smereka, Y., Dmytriiev, D. Tags: 05.01 - Airway pharmacology and treatment Source Type: research