Molecules, Vol. 27, Pages 8362: The Biosynthesized Zinc Oxide Nanoparticles & rsquo; Antiviral Activity in Combination with Pelargonium zonale Extract against the Human Corona 229E Virus

Molecules, Vol. 27, Pages 8362: The Biosynthesized Zinc Oxide Nanoparticles’ Antiviral Activity in Combination with Pelargonium zonale Extract against the Human Corona 229E Virus Molecules doi: 10.3390/molecules27238362 Authors: Abdulsalam A. Alqahtani Mohamed A. El Raey Eman Abdelsalam Ammar M. Ibrahim Omaish Alqahtani Zenab Aly Torky Hany G. Attia Almost one-third of all infectious diseases are caused by viruses, and these diseases account for nearly 20% of all deaths globally. It is becoming increasingly clear that highly contagious viral infections pose a significant threat to global health and economy around the world. The need for innovative, affordable, and safe antiviral therapies is a must. Zinc oxide nanoparticles are novel materials of low toxicity and low cost and are known for their antiviral activity. The genus Pelargonium was previously reported for its antiviral and antimicrobial activity. In this work, Pelargonium zonale leaf extract chemical profile was studied via high-performance liquid chromatography (HPLC) and was used for the biosynthesis of zinc oxide nanoparticles. Furthermore, the antiviral activity of the combination of P. zonale extract and the biosynthesized nanoparticles of ZnO against the human corona 229E virus was investigated. Results revealed that ZnONPs had been biosynthesized with an average particle size of about 5.5 nm and characterized with UV, FTIR, TEM, XRD, and SEM. The antiviral activity showed signific...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research