81. Discrepancies in the detection of PML::RARA gene rearrangement by FISH using commonly used dual-color dual-fusion probes

Acute promyelocytic leukemia (APL) is a medical emergency with serious complications (e.g., DIC), requires prompt treatment and rapid test turnaround time (TAT) for diagnosis confirmation. APL results from a fusion of the PML gene (15q24) with the RARA gene (17q21) creating a fusion gene on the derivative chromosome 15. There are multiple breakpoints that can occur. PML::RARA is the most common (98%) rearrangement. Fluorescent in situ Hybridization (FISH) study helps in the diagnosis of APL with rapid TAT.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research