104. H3K27-altered diffuse midline gliomas with secondary driver molecular alterations

Large-scale sequencing efforts have identified co-occurring driver events, such as activating mutations in FGFR1 and BRAF, in occasional diffuse midline gliomas (DMGs) H3K27-altered, but their significance is incompletely explored. To better understand the clinicopathologic features of these tumors, we identified all H3K27-mutant gliomas from our internal sequencing database (2013-2021) of over 2,000 gliomas and collected detailed clinical information, pathologic features, mutational signatures, and copy number profiles for the resulting cohort.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: David Meredith, Catherine Gestrich, Kristina Grieco, Hart Lidov, Keith Ligon, Sandro Santagata, Kee Kiat Yeo, Sanda Alexandrescu Source Type: research