105. Clinical whole-genome sequencing identifies NSD3 as the correct fusion partner of NUP98 in a patient with acute myeloid

Only rare cases of acute myeloid leukemia (AML) have been shown to harbor a t(8;11)(p11.2;p15.4). This translocation is believed to involve the fusion of NSD3 or FGFR1 with NUP98; however, apart from targeted mRNA quantitative PCR analysis, no molecular approaches have been utilized to define the chimeric fusions present in these rare cases.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Bahareh Mojarad, Zachary Crees, Molly Schroeder, Zhifu Xiang, Justin Vader, Jason Sina, John Frater, Eric Duncavage, David Spencer, Julie Neidich, Kory Lavine, Ina Amarillo Source Type: research