Viruses, Vol. 14, Pages 2614: Bacteriophage Cocktails in the Post-COVID Rehabilitation
Viruses, Vol. 14, Pages 2614: Bacteriophage Cocktails in the Post-COVID Rehabilitation
Viruses doi: 10.3390/v14122614
Authors:
Fedor M. Zurabov
Ekaterina A. Chernevskaya
Natalia V. Beloborodova
Alexander Yu. Zurabov
Marina V. Petrova
Mikhail Ya. Yadgarov
Valentina M. Popova
Oleg E. Fatuev
Vladislav E. Zakharchenko
Marina M. Gurkova
Ekaterina A. Sorokina
Egor A. Glazunov
Tatiana A. Kochetova
Victoria V. Uskevich
Artem N. Kuzovlev
Andrey V. Grechko
Increasing evidence suggests that gut dysbiosis is associated with coronavirus disease 2019 (COVID-19) infection and may persist long after disease resolution. The excessive use of antimicrobials in patients with COVID-19 can lead to additional destruction of the microbiota, as well as to the growth and spread of antimicrobial resistance. The problem of bacterial resistance to antibiotics encourages the search for alternative methods of limiting bacterial growth and restoring the normal balance of the microbiota in the human body. Bacteriophages are promising candidates as potential regulators of the microbiota. In the present study, two complex phage cocktails targeting multiple bacterial species were used in the rehabilitation of thirty patients after COVID-19, and the effectiveness of the bacteriophages against the clinical strain of Klebsiella pneumoniae was evaluated for the first time using real-time visualization on a 3D Cell Explorer microscope. Application of phage cocktails for two week...
Source: Viruses - Category: Virology Authors: Fedor M. Zurabov Ekaterina A. Chernevskaya Natalia V. Beloborodova Alexander Yu. Zurabov Marina V. Petrova Mikhail Ya. Yadgarov Valentina M. Popova Oleg E. Fatuev Vladislav E. Zakharchenko Marina M. Gurkova Ekaterina A. Sorokina Egor A. Glazunov Tatiana A Tags: Article Source Type: research
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