Live recombinant Newcastle disease virus vectored vaccine expressing the haemagglutinin of H9N2 avian influenza virus suppresses viral replication in chickens

In this study, rK148/Y280-HA, a novel recombinant Newcastle disease virus (NDV) vectored vaccine against Y280 lineage H9N2 LPAI was developed and evaluated using two mass-applicable administration methods, spray vaccination and drinking water vaccination. Regardless of low serum antibody haemagglutination inhibition titres against NDV and Y280 lineage H9N2 LPAI after applying the rK148/Y280-HA vaccine, vaccination with both administration methods protected chickens against virulent NDV and Y280-lineage H9N2 LPAIV after the challenge. Taken together, these results indicate that the rK148/Y280 vaccine can be administered using facile mass-application methods to provide protection against the Y280-lineage LPAI.PMID:36377478 | DOI:10.1080/03079457.2022.2148516
Source: Avian Pathology - Category: Pathology Authors: Source Type: research