What is the cause of central cyanosis in Osler-Weber-Rendu syndrome?

What is the cause of central cyanosis in Osler-Weber-Rendu syndrome? Central cyanosis in Osler-Weber-Rendu syndrome is due to pulmonary arteriovenous fistula. Those with Osler-Weber-Rendu syndrome or hereditary hemorrhagic telangiectasia have multiple capillary hemangiomas on skin, lips, mucosa of nose, upper and lower respiratory tract and gastrointestinal tract. Central cyanosis can occur when there are multiple pulmonary arteriovenous fistulae with significant right to left shunt allowing desaturated blood to reach the systemic circulation.
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs